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Can you get high on cocaine?

Yes, you can get high on cocaine.
In fact, you get high really fast when taking cocaine by snorting, smnoking, or injection. While cocaine has limited clinical uses as a local anesthetic in some part of the world, most people wonder, “ Is cocaine addictive or not?” To be clear, cocaine is one of the most addictive and widespread illicit drugs of abuse in the U.S. How does it feel to get high on cocaine and what are the risks of cocaine abuse? We review here. And then we invite your questions about when to treat cocaine addictionat the end.
Cocaine chemistry and use
Cocaine is an alkaloid ester extracted from the leaves of coca. As a strong central nervous system (CNS) stimulant, cocaine interferes with the reabsorption process dopamine, a chemical messenger associated with control over pleasure and movement. Similarly, cocaine interferes with the uptake of norepinephrine and serotonin (5-HT), leading to accumulation of these neurotransmitters at postsynaptic receptors. As a local anesthetic, cocaine reversibly blocks the initiation and conduction of the nerve impulse. Cocaine additionally produces vasoconstriction and dilated pupils.
Medicinally used cocaine is administered as local anesthesia. The ability to trigger vasoconstriction is clinically used particularly in the areas around the eyes and ears, as well as the nose and throat. The name clinically used cocaine is “COCAINE HYDROCHLORIDE: Topical Solution”.
Euphoric effect of cocaine
The effects of cocaine to the central nervous system are very similar to those induced by amphetamines. Cocaine disables the reuptake of dopamine by blocking the dopamine transporter … which leads to increased extracellular dopamine, resulting in stimulation of postsynaptic dopamine receptors. Chronic stimulation of the receptors causes the feeling of euphoria, which starts rather suddenly with arush of emotions and thoughts. But, the same way dopamine levels are affected when cocaine is present, the brain reacts inversely after a cocaine high. When levels of dopamine return to normal, their available drastically drops down. This is what users report to as a “dysphoric” crash.
Cocaine’s central nervous system effects
Cocaine affects the central nervous system in a way that many body functions are inhibited. With repeated use of cocaine, long term changes to brain function can leave permanent damage. Furthermore, the cerebral grey matter in the brain can face atrophy after long term use of cocaine leading to permanent damage of brain cells. Cocaine use also affects the metabolism of glucose in the frontal and temporal lobes, which are significantly decreased.
How does cocaine work to trigger a high?
Cocaine interferes with the way the brain functions, by changing dopamine levels. One of the reasons for this is the fact that cocaine travel quickly through the blood, binding over 90% with plasma and is extensively metabolized to a variety of compounds.
Cocaine’s bioavailability depends on the route of administration and is between 57% following snorting and ~70% following smoking. Some typical cocaine metabolite compounds include: benzoylecgonine, ecgonine, and ecgonine methyl ester. Benzoylecgonine is the major urinary metabolite. Norcocaine is a very minor metabolite, but important for the users because it is neurotoxic. Cocaine has a very short half-life compared to the half-life of cocaine’s metabolites The cocaine half-life is approximately 0.8 ± 0.2 hours, while the half-life of benzoylecgonine is up to 6 hours.
Mixing cocaine with other substances
Cocaine is often mixed intentionally in combination with other drugs. When you inject cocaine with heroin, it’ called “speedball”. Users often combine cocaine with alcohol in order to reduce the irritability they experience. However, this can produce cocaethylene, which can be cardiotoxic. Cocaethylene is an active metabolite which blocks dopamine reuptake. Cocaine is also smoked with phencyclidine, which is known as “tick”, or in blunts with marijuana, called “turbo”.

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Guilt and shame in addiction recovery: 10 activities to help cope

10 Tips for how to cope with feelings of guilt in addiction recovery
1. Face it.
Face the feelings of guilt. Release feelings of guilt by talking about them, sharing, confessing, getting honest.
2 Learn to forgive yourself.
Do you judge yourself too harshly?
3. Examine the origins of your guilt.
Is the reason that you feel guilt rational and reasonable? Inappropriate or irrational guilt involves feeling guilty in relation to something that in reality you had little or nothing to do with or in relation to something that in reality was beyond your control.
4. Change.
Change the related behavior so that the action or actions triggering feelings of guilt and remorse cease. Simply put: If something you are doing is causing you to feel guilty, then stop doing it and you will no longer have a reason to feel guilty any longer.
5. Clarify.
Clarify new values for yourself and take realistic action in the present instead of dwelling on the past. Think about positive action you can take in your life now to feel better. You are never too old to reevaluate your goals, values and priorities for the better
6. Practice.
Practice forgiving others, helping others and doing good for others. Learning to empathize and forgive others can help you to learn to forgive yourself.
7. Apologize or just seek peace.
Is there something you can say or do in order to try to show that you are willing to make peace where there has been hurt, conflict, or disagreement?
8. Let go.
The past is the past, so at some point, even if there are things you have done to hurt others, if you are sorry now, you need to let them go. Or, if you are truly remorseful over something you have done wrong in the past and you tried to make peace or amends, you can still forgive yourself even when others do not forgive you. By the same token, if someone who hurt you is sorry, learn to let it go yourself so you can forget about the hurt and then focus on moving forward
9.Commit to the present.
Was there a legitimate cause for your past actions that was beyond your control at the time? For example, perhaps you hurt others while you were experiencing untreated mental illness or as the result of active drug or alcohol addiction that you are now making efforts to properly care for. Instead focus on behavior change which will influence better decisions in the present and future.
10. Avoid shame.
Shame is a basic feeling of inferiority. Shame involves the perception of oneself as a failure or feeling unacceptable to others. Shame can involve feeling “flawed” “unworthy” or “not good enough”.
Shame often involves forgetting or disregarding the fact that we are human and we make mistakes but that alone does not make us less of a person. Shame is about self- blame and is directly linked to low self-esteem. Shame often comes from the negative messages we may have received as children from our family of origin. (People who were put down or insulted as children, either directly or indirectly, may end up much more prone to shame-based thinking as adults, although this does not always have to be the case)
Getting past guilt
Irrational thoughts and beliefs can fuel shame and inappropriate guilt. These untruths can perpetuate negative feelings we have about ourselves. Take a look at these statements, and check your own beliefs regarding them.
*.I must get everyone’s approval.
*.I must be perfect.
*.Mistakes are bad.
*.If I am not like ________ then I am not a valuable person.
*.Everyone can see my faults.
*.I am not worthy of forgiveness.
Put it into practice
Think of the rational and reasonable alternative for each of the above shame-based thoughts. For example, for the first one, “In must get everyone’s approval” the more rational alternative might be something like, “I can still feel good about myself even if some people do not approve of me”. Try this for the rest of the statements above. It is worth it not to give up on working through your guilt and shame issues.

The Danger of the Monster Myth

samson:

When there’s a particular group
affected disproportionately by a
particular phenomenon and another
particular group, it’s more than okay to
look at why that is and how it can be
changed and challenged;

Originally posted on White Ribbon Campaign:

Tom Meagher

One of the most disturbing moments of the past eighteen months of my life was hearing my wife’s killer form a coherent sentence in court. Jill had been murdered almost six months earlier, and Adrian Bayley’s defence team were presenting a rather feeble case for a four-week adjournment of his committal hearing. Bayley appeared via video-link as I sat flanked by two friends and a detective. The screen was to my right, mounted high up and tilted slightly towards the bench. It was uncomfortably silent apart from the occasional paper shuffle or short flurry of keyboard clicks. I anticipated, and prepared for the most difficult moment of the day when Bayley’s face appeared on the big-screen TV, looming over the seat I then occupied. When that moment arrived, a jolt of nausea came and went, but the worst was to come, made all the more horrifying because it was…

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This woman exercised her right to abort her infants, and now she’s being unjustly persecuted

Originally posted on The Matt Walsh Blog:

HT_megan_huntsman_blur_h_jt_140413_16x9_992

Someone get this printed on a t-shirt:

“Free Megan Huntsman!”

Slap it on a bumper sticker. Start the campaign.

Megan Huntsman — every bit the same sort of feminist hero as Planned Parenthood CEO Cecile Richards or Abortion Martyr George Tiller — is being persecuted. Prosecuted and persecuted before our very eyes (in the year 2014!) all for allegedly making a choice. A difficult choice, mind you. An alleged choice that she must have grappled with torturously.

She considered her options and, in the end, came to the conclusion that she wasn’t ready to be a mother. So she terminated her post-birth fetuses — six of them — and put them in boxes in her garage, according to the charges.

Police say that Ms. Huntsman has admitted to conducting this medical procedure, and why shouldn’t she admit to it? Why shouldn’t she have the freedom to make decisions about her life and her body…

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How long does cocaine last?

What are the effects of cocaine on the brain,
how long does cocaine work, and is cocaine
detectible in body fluids (cocaine in blood,
hair, or urine)? Here, we review the way
cocaine affects the brain and body, its
duration and determinants of intensity. Your
questions about finding help for cocaine
addiction are invited at the end.
Cocaine effects on the body and brain
Acting as a strong central nervous system
stimulant, cocaine increases the levels of
dopamine (a neurotransmitter in the brain),
which helps regulates both pleasure and
movement. When cocaine is present, it
causes serious disruption of the neurons
and their activities in the brain and central
nervous system. Cocaine prevents dopamine
from being brought back to the cell that
released it, which allows dopamine build up
in the nerve synapse (the space between
nerve cells). In this way, dopamine released
by cocaine acts as a destructive signal,
manifesting malfunctions in internal brain
communication with transmitters. This is the
main reasons why users feel euphoric when
high on cocaine.
However, repeated use of cocaine can cause
many short and long-term effects on the
body and brain, each requiring medical
attention. Furthermore, one of the most
common mistakes that cocaine users make,
especially relatively new ones, is to try to
achieve the highest level of euphoria with
first dose. However, fatalities from cocaine
overdose can occur, even within previous
drug dosing and considering tolerance
levels.
Cocaine duration of action
Cocaine duration of action depends first
upon mode of administration. Cocaine
effects are different when administered by
smoking, snorting, or iv injection. In fact,
these methods becomes even more
dangerous for the short and long term
effects on your health, due to the rapid
absorption of cocaine into your system. The
basic relationship is this: the faster the
absorption, the faster the high from cocaine
but the shorter the duration of effect. Here
are some key points to consider:
Despite the fact that main cocaine
metabolites, such as ecgonine methyl
ester, are centrally inactive, cocaine
manages to be bound in plasma up to
90%.
Injecting cocaine produces effect within
30 seconds, but after oral administration,
general effects will last for 2 hours.
Post-effects of cocaine may continue for
days, especially with binge use.
Bioavailability reaches up to 70% after
smoking cocaine, meaning that the brain
is affected almost instantly.
Additionally, the
presence of cocaine in the bloodstream can
not directly be associated with a certain level
of impairment or specific effects without
additional information. The level of
individual tolerance to cocaine and minor
artificial changes to cocaine during storage
also act their role in the length and strength
of effects.
How long do cocaine effects last?
Dosing of cocaine is differentiated from the
significant overlap of between therapeutic,
toxic, and lethal cocaine concentrations in
patients and addicts. Furthermore, repeated
doses, also called binge use, can make a big
difference on cocaine effects in the system.
For a comparison, here is a list of cocaine
doses taken through different routes,
reaching plasma concentration peak levels
at different time windows.
A single dose of 30mg taken through
intravenous injection, reaches peak levels
only after 5 minutes.
After snorting a dose of 100mg cocaine,
peak levels in plasma concentrations are
reached 30 minutes later.
When 50mg of cocaine base are smoked,
peak plasma concentrations are produced
within 45 minutes.
After orally taking 140 mg/70 kg of
cocaine, peak levels are reached after 1
hour.
Cocaine time in the body
Cocaine has a very short half-life of only 0.2
-0.8 hours. However, that does not mean
that effects or evidence of cocaine are
eliminated during this time.
Benzoylecgonine, one of the main cocaine
metabolites, can be present in urine for up
to 4 days. This number is more than double
for heavy chronic cocaine users, mainly
following a binge use. Up to 2% of cocaine
manages to leave the body unchanged
through urine and about 70% of the initial
amount of cocaine is recovered after 3 days.
How long does a cocaine high last?
The intensity and duration of high effects of
cocaine depend on the way it is
administered. In order to prolong their high
pleasurable effects, user often practice
binge use, where doses of cocaine are
repeatedly taken within a relatively short
period of time. While the user is still high
from the last dose, he decides to go for
another one. However, practicing this
dangerous technique can often lead to
addiction, a chronic relapsing disease.
Addiction to cocaine is caused by drastic
changes in the brain, of which the user is
not aware, which results in strong cravings
and constant compulsion for cocaine use,
neglecting the negative consequences to
health and environment.
Cocaine high effects
Cocaine high effects are almost nothing like
any other drug, according to users. The high
from cocaine usually consists of two phases.
The early phase is mainly psychological and
consists of euphoria, excitation, feelings of
well-being, general arousal, increased sexual
excitement, dizziness, self-absorbed,
increased focus and alertness, mental clarity,
increased talkativeness, motor restlessness,
offsets fatigue, improved performance in
some simple tasks, and loss of appetite.
Higher doses may exhibit a pattern of
psychosis with confused and disoriented
behavior, delusions, hallucinations,
irritability, fear, paranoia, antisocial
behavior, and aggressiveness. Physiological
effects of cocaine use include increased
heart rate and blood pressure, increased
body temperature, dilated pupils, increased
light sensitivity, constriction of peripheral
blood vessels, rapid speech, dyskinesia,
nausea, and vomiting.
The late phase of cocaine effects include
psychological symptoms such as dysphoria,
depression, agitation, nervousness, drug
craving, general CNS depression, fatigue, or
insomnia. Physiological symptoms of late
phase cocaine use include itching/picking/
scratching, normal heart rate, normal pupils.
Cocaine duration questions
After reading this article, do you still have
some questions about cocaine? If you
would like to know more about how long
cocaine lasts, please post your question(s)
and share your comment(s) in the next
section. We will try to answer you personally
and promptly.

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Optimism: Key to Doing Great Things

In 2011, Paul Graham published an essay titled Why Startup Hubs Work. There he wrote about what makes a startup hub, like Silicon Valley, works. Here is an excerpt:
… it is a particularly valuable thing when the atmosphere around you encourages you to do something that would otherwise seem too ambitious. In most places the atmosphere pulls you back toward the mean.
I flew into the Bay Area a few days ago. I notice this every time I fly over the Valley: somehow you can sense something is going on. Obviously you can sense prosperity in how well kept a place looks. But there are different kinds of prosperity. Silicon Valley doesn’t look like Boston, or New York, or LA, or DC. I tried asking myself what word I’d use to describe the feeling the Valley radiated, and the word that came to mind was optimism.
Optimism. That’s the key attitude that the Valley has. That’s the key attitude behind creative ventures such as Google, Facebook, and many others. That’s what makes the people in the Valley dare to work on things that are normally considered too ambitious.
I believe that optimism is an attitude that you, as an individual, must also have.If you want to get the most out of your life, optimism is key. Optimism here meansa sense of unlimited possibilities about your future.It’s the belief that, when it comes to your future, nothing is impossible. Your surroundings might not be ideal, but that won’t hinder you from being what you’re supposed to be.
Optimism will change the way you work. You will be energized. You will approach your days with enthusiasm. You will be more creative since you believe there must be a way.
The road won’t be easy. You will have to go through difficulties. But having the right attitude is key. Put optimism in your arsenal. Believe there are unlimited possibilities about your future. Then, and only then, will you start making things happen.

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Consequences of driving drunk

If you’ve ever wondered how alcohol makes
you drunk and whether or not alcohol can
really impair your driving, you’re in the right
place. Here, we review the impact of drunk
driving, as well as consider alternatives to
mandatory jail time, including questions on
DUI assessments, drug courts, or addiction
treatment. Then, we invite your questions
about drunk driving or its consequences at
the end.
Every 2 minutes…
Sit out front of a coffee shop. Turn and look
to the left. Now, turn and look to the right.
Zoom in on at least three people and study
them. They may be walking by, cycling by,
maybe sitting at another table; old, young,
male, female, doesn’t matter. Study them for
a minute or two. What are they wearing?
Are they laughing, walking their dog,
running, having a cup of coffee while
chatting on their phone with a friend?
Time’s up.That went by fast didn’t it? In
those two minutes; someone, somewhere
was injured in an automobile accident that
involved a drunk driver. One of the three
people you chose to watch will be involved
in an accident involving a drunk driver in
their lifetime, and probably not as the driver.
The High Cost of Drunk Driving
Maybe they will be injured for life, ending up
in a wheelchair, or on life support. Maybe
they will die. Maybe it will be today. Which
one; the girl in the pretty red sweater?
Maybe it will be the man in the business suit
grabbing coffee on his way to the office, or
the mom pushing her twins in a stroller?
Think about them every time you’ve had too
much to drink and get behind the wheel of
your car.
Morbidity and consequences of drunk
driving
Every 30 minutes someone is killed by a
drunk driver. A consequence no one wants
to live with. Other (unforeseen)
consequences of drunk driving can include:
car used in the crime can be impounded
(fees apply)
community service
hefty lawyer’s fees
increase in auto insurance rates
killing an innocent friend, family member,
another human being, or yourself
maiming or killing others or yourself
mandatory jail time, can be lengthy with
mitigating circumstances
may not be able to rent a car when
needed
possible job loss and trouble getting a
new job
suspended driver’s license
Treatment Instead of Jail Time?
While some states in the U.S. allow the
option of alcohol abuse treatment instead of
jail time; the consequences associated with
drunk driving are many and differ from
state to state. The DUI consequences
website provides information on the legal
consequences of drunk driving by state and
which states allow treatment instead of jail
time.
Get Out of Jail Free Card
According to the Wolford Law Firm, judges
in some states have the option of imposing
alcohol abuse treatment, known as sober
living, DUI treatment, or rehab, as opposed
to a jail sentence for a DUI (driving under
the influence) or DWI (driving while
intoxicated). Studies have proven alcohol
abuse treatment to be more effective than
jail time in helping alcoholics recover and
live a life of sobriety. However, how long a
DUI stays on a record, as well as sentencing
laws, vary by state.
As an example; California includes sober
living as an alternative to a jail sentence for
DUI’s and DWI’s in its penal code. Time spent
in a rehabilitation treatment center with DUI
rehab and sober living programs substitutes
for incarceration providing the long term
assistance that may be needed.
If you’ve been arrested for a DUI or DWI,
seek help from a rehab facility that
specializes in DUI treatment. They may be
able to help you stay out of jail and get the
help needed to reach and maintain a life
free from alcohol addiction.